COVID-19: Brescia-COVID Respiratory Severity Scale / ICU Outcomes

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We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

https://www.mdcalc.com/brescia-covid-respiratory-severity-scale-bcrss-algorithm#evidence
Bhatraju et al. NEJM

Also, please check out Brief19.com for the latest research and policy updates regarding COVID-19

COVID-19: Awake Proning, Hydroxychloroquine Update, Neonatal Update

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We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Also, please check out Brief19.com for the latest research and policy updates regarding COVID-19

Sun et al. Ann. Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province. Intensive Care (2020) 10:33
Ding et al. Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study. Critical Care. 24(28). 2020

COVID-19: SARS-CoV-2 in the air + Convalescent Plasma

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We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Also, please check out Brief19.com for the latest research and policy updates regarding COVID-19

Santarpia et al – Pre-print
Shen et al. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA 2020.In press

COVID-19: Vertical Transmission in Pregnancy and HFNC Update

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We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Also, please check out Brief19.com for the latest research and policy updates regarding COVID-19

Zeng H, Xu C, Fan J, et al. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. 2020;
Dong L, Tian J, He S, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020;
https://content.vapotherm.com/hubfs/COVID-19%20Transmission%20Assessment%20Report.pdf

COVID-19: Timeline of Disease and Viral Shedding

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We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Also, please check out Brief19.com for the latest research and policy updates regarding COVID-19

1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;6736(20):1–9.
2. Wu C, Chen X, Cai Y, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med 2020;1–10.
3. Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic Features and Clinical Course of Patients Infected with SARS-CoV-2 in Singapore. JAMA – J Am Med Assoc 2020;1–7.
4. Arentz M, Yim E, Klaff L, et al. Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. Jama 2020;4720:2019–21.
5. He X, Lau EH, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. medRxiv 2020;2020.03.15.20036707.
6. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497–506.
Bao et al Reinfection could not occur in SARS-CoV-2 infected rhesus macaques [pre-print]

Amanat et al – A serological assay to detect SARS-CoV-2 seroconversion in humans

COVID-19: Atypical Symptoms

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We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.


ENT UK statement
American Academy of Otolaryngology-Head and Neck Surgery statement

Check out Brief19.com for the latest research and policy updates regarding COVID-19. If you’re looking for details on COVID-19, REBELEM and IBCC are excellent, comprehensive resources.

Pan L, et al., Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study, The American Journal of Gastroenterology

COVID19: SARS-CoV-2 Transmission and Masks

Apple Podcasts or Listen Here

We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Check out Brief19.com for the latest research and policy updates regarding COVID-19. If you’re looking for details on COVID-19, REBELEM and IBCC are excellent, comprehensive resources.

Van doremalen N, Bushmaker T, Morris DH, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 2020; 
Goldberg LJ et al. The use of a rotating drum for the study of aerosols over extended periods of time.Am J Hyg. 1958 Jul;68(1):85-93.PMID: 13559215

Hospitals and healthcare agencies across the United States are struggling to obtain adequate personal protective equipment (PPE). As a result, the US Centers for Disease Control and Prevention has created contingency plans for PPE depending on its availability. Recent updates include “crisis” plans which recommend use of bandanas, scarves, or homemade masks (because something is better than nothing). This isn’t uncharted literature territory…

Macintyre CR, Seale H, Dung TC, et al. A cluster randomised trial of cloth masks compared with medical masks in healthcare workers. BMJ Open. 2015;5(4):e006577.

Mills D et al. Ultraviolet germicidal irradiation of influenza-contaminated N95 filtering facepiece respirators. Am J Infect Control. 2018;46(7):e49-e55.

Lindsley WG et al. Effects of Ultraviolet Germicidal Irradiation (UVGI) on N95 Respirator Filtration Performance and Structural Integrity. J Occup Environ Hyg. 2015;12(8):509-17

COVID19: High Flow Nasal Cannula, Cytokine Storm, Asymptomatic Transmission

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We are going to try to bring you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Also, please check out Brief19.com for the latest research and policy updates regarding COVID-19

Cytokine Storm – Mehta et al describe cytokine storm or secondary hamophagocytic lymphohistiocytosis (sHLH), a hyperinflammatory state, which characterizes some presentations of critical COVID-19.

The Society of Critical Care Medicine (SCCM) updated their COVID 19 guidelines (reviewed here), in which high flow nasal cannula (HFNC) was recommended. HFNC is an aerosol generating form of oxygenation so we review some of the data around this, including an article by Will Loh et al.

Asymptomatic transmission and basic reproductive number (Ro). Aguilar et al.

COVID-19: Society of Critical Care Medicine Surviving Sepsis Guidelines #COVID19

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We are going to try to bring you near daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Also, please check out Brief19.com for the latest research and policy updates regarding COVID-19

Today we bring you the Society of Critical Care Medicine (SCCM) Surviving Sepsis COVID-19 Guidelines.

COVID-19: Pregnancy, Breastfeeding, and Investigational Treatments

Apple Podcasts or Listen Here

We are going to try to bring you daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes.

Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med. 2020; In Press