Stop Giving Lidocaine in “GI Cocktails”

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We are trialing a new series of quick literature reviews. Let us know what you think

“GI cocktails” are commonly used in the Emergency Department for epigastric discomfort, but the evidence behind “cocktail” components is lacking and while lidocaine is commonly used, a trial by Berman et al found no benefit (versus a prior RCT in 1990 with high risk of bias).

In this episode we review a new trial by Warren et al on antacids versus antacids with lidocaine for epigastric pain and dyspepsia

COVID-19: Hydroxychloroquine [RECOVERY trial]

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We are bringing you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes. This episode was recorded June 22, 2020

We’ve been looking at a treatment for severe COVID-19 and this massive trial from the United Kingdom, the RECOVERY trial published a pre-print of the results from the hydroxychloroquine arm (previously they published their promising results on dexamethasone). Note: these results are preliminary and have not been peer-reviewed

Hornby et al. [pre-print] supplement