AHA/ACC Pulmonary Embolism Guidelines

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This podcast summarizes a new behemoth guideline from the American Heart Association/American College of Cardiology on the management of pulmonary embolism (PE). The guideline itself can be found here.

Disclosure: Dr. Westafer was on the guideline writing committee; however, the views expressed herein are hers alone and do not reflect the guideline writing committee, the AHA, the ACC or any endorsing organization.

Pulmonary Embolism in Pediatrics: PERC-peds

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Prior literature on pediatric patients with pulmonary embolism (PE) is limited – mostly consisting of patients with malignancy or indwelling lines. Now, we have a prospective study on venous thromboembolism (VTE) evaluation in pediatric patients. The major result is that VTE was common….6.3% of patients with documented medical decision making considering PE, D-dimer, or imaging for PE had objective diagnosis of VTE. The podcast reviews this article: Ellison et al. PERC-Peds rule for bedside exclusion of pulmonary embolism without radiation in children in the USA (BEEPER): a multicentre, prospective, observational, diagnostic accuracy study. Lancet Resp Medicine. 2026. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(26)00086-X/abstract

Thoracic Aortic Dissection: ACEP Clinical Policy Update

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In this episode, we review a new clinical policy from the American College of Emergency Physicians (ACEP) on the use of risk stratification tools (ADD-RS) and D-dimer to exclude non-traumatic thoracic aortic dissection.

https://onlinelibrary.wiley.com/doi/10.1111/acem.13356
Promes SB, Westafer L, Byyny R, Diercks DB et al Critical Issues in the Evaluation and Management of Adult Patients With Suspected Acute Nontraumatic Thoracic Aortic Dissection. Ann Emerg Med. 2025 Jul;86(1):e12-e26. PMID: 40543988. https://pubmed.ncbi.nlm.nih.gov/40543988/
Nazerian Pet al. Diagnostic Accuracy of the Aortic Dissection Detection Risk Score Plus D-Dimer for Acute Aortic Syndromes: The ADvISED Prospective Multicenter Study. Circulation. 2018 Jan 16;137(3):250-258. PMID: 29030346. https://pubmed.ncbi.nlm.nih.gov/29030346/
Nazerian P, Mueller C, Vanni S, et al. Integration of transthoracic focused cardiac ultrasound in the diagnostic algorithm for suspected acute aortic syndromes. Eur Heart J. 2019 Jun 21;40(24):1952-1960. PMID: 31226214. https://pubmed.ncbi.nlm.nih.gov/31226214/

RhD Immunoglobulin (e.g. RhoGAM) After First Trimester Abortion

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Historically, care of patients in the emergency department (ED) in the first trimester with any kind of abortion (e.g. spontaneous “miscarriage”) underwent blood type and Rh testing followed by RhD immunoglobulin prophylaxis if Rh+. However, many guidelines now recommend foregoing this process in first trimester abortion (spontaneous or induced). In this episode, we dive into the evidence behind these varying recommendations.

Visscher RD, Visscher HC Do Rh-negative women with an early spontaneous abortion need Rh immune prophylaxis? Am J Obstet Gynecol. 1972 May 15;113(2):158-65. PMID: 4623673.

Inhaled Corticosteroids for Asthma

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Summary in ACEPNow can be found here

Rayner DG et al. Inhaled Reliever Therapies for Asthma: A Systematic Review and Meta-Analysis. JAMA. 2025 Jan 14;333(2):143-152. doi: 10.1001/jama.2024.22700. PMID: 39465893; PMCID: PMC11519786.

Rayner DG et al. Inhaled Reliever Therapies for Asthma: A Systematic Review and Meta-Analysis. JAMA. 2025 Jan 14;333(2):143-152. doi: 10.1001/jama.2024.22700. PMID: 39465893; PMCID: PMC11519786.

Asthma Management Guidelines: Focused Updates 2020

Atrial Fibrillation Guideline Update from the AHA

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The American Heart Association (AHA) released new clinical practice guidelines on atrial fibrillation (AF). This episode reviews the emergency medicine-related guidelines.

Ramesh T, Lee PYK, Mitta M, Allencherril J. Intravenous magnesium in the management of rapid atrial fibrillation: A systematic review and meta-analysis. J Cardiol. 2021 Nov;78(5):375-381. doi: 10.1016/j.jjcc.2021.06.001. Epub 2021 Jun 20. PMID: 34162502.
Bouida W, et al. Low-dose Magnesium Sulfate Versus High Dose in the Early Management of Rapid Atrial Fibrillation: Randomized Controlled Double-blind Study (LOMAGHI Study). Acad Emerg Med. 2019 Feb;26(2):183-191. PMID: 30025177.

Transfusion Updates: Restrictive vs Liberal Transfusion in Myocardial Infarction

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The Association for the Advancement of Blood & Biotherapies (AABB) released 2023 International Red Blood Cell Transfusion Guidelines. This podcast reviews the guidelines as well as a recently released trial evaluating restrictive versus liberal transfusion strategy in patients with myocardial infarction. Carson et al. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. NEJM 2023. DOI: 10.1056/NEJMoa2307983.

AABB Red Blood Cell Transfusion 2023 International Guidelines
Carson et al. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. NEJM 2023. DOI: 10.1056/NEJMoa2307983
Carson et al. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. NEJM 2023. DOI: 10.1056/NEJMoa2307983
Carson et al. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. NEJM 2023. DOI: 10.1056/NEJMoa2307983