Vaccine-Induced Thrombotic Thrombocytopenia

Apple Podcasts , Spotify, Listen Here

In this episode, we discuss thrombotic thrombocytopenia associated with the viral vector COVID-19 vaccines (VITT: Vaccine-Induced Thrombotic Thrombocytopenia) – a very very rare, but real entity. Information is still emerging so numbers will likely change in the coming days. For more on cerebral vein thrombosis in general, check out this podcast.

Greinacher et al NEJM 2021
Schultz et al. NEJM 2021
ACIP Presentation by Jannsen 4/14/21, Muir et al NEJM 2021

International Society of Thrombosis and Hemostasis Statement

United Kingdom Guidance On Thrombosis Following Vaccinations

Cerebral Vein Thrombosis

Apple Podcasts , Spotify, Listen Here

If you’re looking for vaccine-induced thrombotic thrombocytopenia (CVT/CVST with thrombocytopenia following AstraZeneca or J&J COVID-19 vaccine), check out this podcast.

Multicenter Cohort Study: Ferro JM et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004 Mar;35(3):664-70. Epub 2004 Feb 19. PMID: 14976332.

Utility of D-dimer:

  1. Dentali F et al. D-dimer testing in the diagnosis of cerebral vein thrombosis: a systematic review and a meta-analysis of the literature. J Thromb Haemost. 2012 Apr;10(4):582-9.PMID: 22257124.
  2. Meng R et al. Evaluation of plasma D-dimer plus fibrinogen in predicting acute CVST. Int J Stroke. 2014 Feb;9(2):166-73. Epub 2013 Mar 19. PMID: 23506130