COVID-19: Is it ARDS? HAPE? Hemoglobinopathy?

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We are bringing you near-daily updates on COVID-19. There is a firehose of information and most of us are too busy to read and digest it all. Note: If you are listening to these more than a few days in the future, please beware that information may have changed and check subsequent episodes. Today we are joined by Dr. Rory Spiegel of EMNerd to discuss various theories and possible mechanisms for the clinical picture we see with severe COVID-19.

Gattinoni L, Coppola S, Cressoni M, Busana M, Chiumello D. Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2020; In press

Many people have been talking about the “hemoglobin hijacking” of COVID-19 but this is far from a certain theory and really only from a single computer simulation model.

It appears that hypoxic vasoconstriction is the most robust explanation at this time. This has led to some drawing parallels to high altitude pulmonary edema (HAPE).

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